- Title
- Erythrocyte omega-3 polyunsaturated fatty acid levels are associated with biomarkers of inflammation in older Australians
- Creator
- Olliver, Melinda; Veysey, Martin; Lucock, Mark; Niblett, Suzanne; King, Katrina; MacDonald-Wicks, Lesley; Garg, Manohar L.
- Relation
- ARC.LP0883378 http://purl.org/au-research/grants/arc/LP0883378
- Relation
- Journal of Nutrition and Intermediary Metabolism Vol. 5, Issue September 2016, p. 61-69
- Publisher Link
- http://dx.doi.org/10.1016/j.jnim.2016.03.002
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2016
- Description
- Background: Elevated levels of pro-inflammatory mediators heighten the risk of developing or aggravating a spectrum of chronic diseases and are a strong predictor of mortality in elderly cohorts. Omega-3 polyunsaturated fatty acids (n-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are known to possess anti-inflammatory properties. However, the relationship between erythrocyte membrane n-3PUFA and inflammation biomarkers has not been well established. Objective: This study aimed to determine if n-3PUFA status, together with the omega-3 index (O3I, erythrocyte membrane % EPA plus DHA), is associated with pro-inflammatory mediators in older Australians. Methods: The study was a cross-sectional analysis of randomly selected older men and women aged ≥65 years (n = 620) recruited from the Central Coast of NSW, Australia. Fasted blood samples were analysed for C-reactive protein (CRP), fibrinogen and full blood count using standardised laboratory methods. The fatty acid composition of erythrocyte membranes was analysed via gas chromatography to determine n-3PUFA levels. The relationships between n-3PUFA and inflammatory mediators were evaluated in multivariate regression models after adjusting for known inflammatory confounders. Results: After excluding participants who had an inflammatory disease, CRP levels >10 mg/L, or who were taking anti-inflammatory medications or n-3PUFA supplements, 126 participants (age 77.6 ± 7.3 years; females, 46%) were included in the analysis. After multivariate adjustments, O3I was inversely associated with CRP (β = −0.209, p < 0.05) and monocyte cell counts (β = −0.205, p < 0.05), and total n-3PUFA was inversely related to WBC (β = −0.238, p < 0.05), neutrophils (β = −0.212, p < 0.05) and monocytes (β = −0.246, p < 0.05). However no association between fibrinogen and O3I or total n-3PUFA was detected. Conclusions: This study demonstrated a negative association between O3I and biomarkers of inflammation in an older population. The findings support a potential role for n-3PUFA supplementation in the management of inflammatory diseases.
- Subject
- omega-3 polyunsaturated fatty acids; omega-3 index; inflammation; C-reactive protein; fibrinogen; white blood cells; monocytes; neutrophils; ageing
- Identifier
- http://hdl.handle.net/1959.13/1345549
- Identifier
- uon:29666
- Identifier
- ISSN:2352-3859
- Rights
- © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
- Language
- eng
- Full Text
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